Amoxicillin/clavulanic acid(augmentine) uses,side effect,

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Amoxicillin/clavulanic acid;-

Amoxicillin/clavulanic acid;-(augmentine)

Amoxicillin/clavulanic acid or co-amoxiclav is an antibiotic useful for the treatment of a number of bacterial infections. It is a combination antibiotic consisting of amoxicillin trihydrate, a β-lactam antibiotic, and potassium clavulanate, a β-lactamase inhibitor. This combination results in an antibiotic with an increased spectrum of action and restored efficacy against amoxicillin-resistant bacteria that produce β-lactamase.

medical uses;-

Amoxicillin/clavulanic acid is widely used to treat or prevent many infections caused by susceptible

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bacteria, such as:
urinary tract infections
respiratory tract infections
skin and soft tissue infections
sinus infections
cat scratches
infections caused by the bacterial flora of the mouth, such as:
dental infections
infected animal bites
infected human bites

History.

British scientists working at Beecham (now part of GlaxoSmithKline), filed for US patent protection for the drug combination in 1979.

A patent was granted in 1985.

Bactrerial Resistance

Bacterial antibiotic resistance is a growing problem in veterinary medicine. Amoxicillin/clavulanic acid is reported to be effective against clinicalKlebsiella infections, but is not efficacious against Pseudomonas infections.

Adverse effects;-

Possible side effects include diarrhea, vomiting, nausea, thrush, and skin rash. These do not usually require medical attention. As with all antimicrobial agents, antibiotic-associated diarrhea due to Clostridium difficile infection—sometimes leading to pseudomembranous colitis—may occur during or after treatment with amoxicillin/clavulanic acid.

Rarely, cholestatic jaundice (also referred to as cholestatic hepatitis, a form of liver toxicity) has been associated with amoxicillin/clavulanic acid. The reaction may occur up to several weeks after treatment has stopped, and usually takes weeks to resolve. It is more frequent in men, older people, and those who have taken long courses of treatment; the estimated overall incidence is one in 100,000 exposures. In the United Kingdom, co-amoxiclav carries a warning from the Committee on Safety of Medicines to this effect.